New findings on the role of Omega-3 in psychological stress
Depression is one of the most common mental health challenges worldwide, affecting millions of people. A meta-analysis examining the effects of dietary supplements on mental health issues was published in the journal World Psychiatry , the official journal of the World Psychiatric Association, highlighting omega-3 fatty acids as potentially helpful. A research team led by the NICM Health Research Institute in Sydney analyzed 33 randomized controlled trials with data from approximately 11,000 people diagnosed with mental health conditions.
What do the results show?
Although many dietary supplements showed no significant effects on mental well-being, some—particularly omega-3 fatty acids—were considered potentially helpful in certain cases. According to the authors, these supplements are generally considered safe and well-tolerated when used at the recommended dosage and under medical supervision, even in combination with prescribed medications.
Omega-3 fatty acids for depressive symptoms
The clearest evidence was found in individuals with major depression. In some studies, participants who supplemented with omega-3 fatty acids reported a positive change in their mood—particularly compared to groups that used antidepressants alone. Supportive effects have also been observed in individual cases in attention and behavioral disorders such as ADHD.
Professional recommendations
In September, the International Society for Nutritional Psychiatry Research (ISNPR) published evidence-based recommendations for the adjunctive use of omega-3 fatty acids in depressive disorders. The guidelines address various aspects, including adjunctive strategies for acute treatment, relapse prevention, and individualized use in specific risk groups. Targeted supplementation could be particularly beneficial for individuals with low omega-3 index or elevated inflammatory levels – subject to medical evaluation.
Biochemical background
Omega-3 fatty acids—particularly EPA and DHA—play a structural role in brain cell membranes and interact with mood-related neurotransmitters such as serotonin. Their inflammation-modulating properties are also discussed as a possible explanation for observed effects.
A study published in the Journal of the American College of Cardiology: Heart Failure examined the association between blood omega-3 levels and depressive symptoms in people with chronic heart failure. A daily supplement with 2 grams of EPA/DHA was associated with improvements in mood and psychomotor symptoms.
Omega-3 index values reached 6.79% in the EPA/DHA group, 6.32% in the EPA group, and 4.61% in the placebo group. Furthermore, statistical correlations were found between higher omega-3 levels and lower scores on the Beck Depression Inventory II (BDI-II) , one of the most commonly used questionnaires for assessing depressive symptoms.
Classification by experts
Dr. Bill Harris, co-author of the study and developer of the Omega-3 Index test, emphasized that this study involved individuals who already had depressive symptoms. Omega-3 supplements can, under certain conditions, be effective as an adjunct to an overall therapeutic strategy—however, higher dosages are required for such applications. "We typically consider omega-3 to be preventative. If it is used to support symptoms, the dosage should be adjusted and blood levels should be checked regularly," said Dr. Harris.
Conclusion
The results underscore the potential of omega-3 fatty acids as a complementary component of a holistic approach to promoting mental stability. Although no general statement regarding efficacy can be made, the findings offer a promising starting point for further research—particularly in individuals with nutritional deficiencies or increased needs.
Note: The use of Omega-3 supplements should always be done in consultation with a medical professional, especially if you have existing mental health conditions or are taking medication.
References: OmegaQuant Website